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Opana Oxymorphone 40mg

Generic Name : oxyMORphone

Brand Name : Opana, Opana ER

Strength : 40 mg

Manufacturered by  Endo Pharmaceuticals Inc.

Drug Class : Narcotic analgesic


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Opana Oxymorphone 40mg

Oxymorphone, commonly known by its brand name Opana Oxymorphone 40mg, is a potent opioid analgesic that is used to treat extreme pain. Being more potent than morphine, it is an opioid that is

semi-synthetic in nature. Opana modifies pain perception by attaching itself to opioid receptors in the brain and spinal cord. Because of its strength, Opana is usually saved for situations when other painkillers aren’t working, and because of the possibility of addiction and respiratory depression, its use needs to be closely monitored.


  • Users of Opana Oxymorphone 40mg run the risk of addiction, abuse, and misuse, which can result in overdosing and fatalities.
  • to guarantee that the advantages of opioid analgesics surpass the dangers associated with addiction, abuse, and misuse.
  • There could be a serious, deadly, or life-threatening respiratory depression. Keep a close eye on things, especially when starting out or after a dose increase.
  • Accidental oxymorphone overdose can be fatal when Opana Oxymorphone 40mg is consumed, especially by young children.
  • Neonatal opioid withdrawal syndrome, which can be fatal if left untreated, can be brought on by long-term use of Opana Oxymorphone 40mg during pregnancy.
  • Patients taking Opana Oxymorphone 40mg should not drink alcohol or use any product containing alcohol while taking it, as this can cause lethal plasma oxymorphone levels.

Indications and Uses of Opana Oxymorphone 40mg:

Opana Oxymorphone 40mg is an opioid agonist prescribed to treat pain that is severe enough to need daily, round-the-clock opioid therapy over an extended period of time when no other treatment works well.

Limitations of Use:

  • As a result of the increased risks of overdose and death associated with extended-release opioid formulations and the risks of addiction, abuse, and misuse associated with opioids even at recommended doses, save Opana Oxymorphone 40mg for use in patients for whom non-opioid analgesics or immediate-release opioids are not working, are not tolerated, or would otherwise not be sufficient to manage pain.
  • As a pain reliever for as-needed (prn), Opana Oxymorphone 40mg is not recommended.

Opana Oxymorphone 40mg Dosage:

  • Only medical professionals skilled in the administration of strong opioids for the treatment of chronic pain should prescribe these medications.
  • In accordance with each patient’s unique treatment objectives, use the lowest effective dosage for the shortest amount of time.
  • Adjust the dosage according to the patient’s response, past analgesic experience, level of pain, and risk factors for addiction, abuse, and misuse.
  • Give the medication empty-handed, at least an hour before or two hours after a meal.
  • It is recommended to take Opana Oxymorphone 40mg tablets one at a time.
  • Every three to seven days, the dosage can be raised by 5 to 10 mg every twelve hours.

Dosage Forms and Strengths:

5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg, and 40 mg extended-release tablets

Drug Interactions:

Serotonergic Drugs: Serotonin syndrome may develop from concurrent use. If you suspect serotonin syndrome, stop taking Opana Oxymorphone.

Partialagonist and Mixed Agonist/Antagonist Opioid Analgesics: Avoid using mixed antagonist/agonist and partial antagonist opioid analgesics with Opana Oxymorphone 40mg as they may lessen the medication’s analgesic effect or hasten the onset of withdrawal symptoms.

Monoamine Oxidase Inhibitors (MAOIs): Have the ability to increase oxymorphone’s effects. Refrain from using concurrently while taking MAOIs or for 14 days after stopping an MAOI’s treatment.


Clinical Presentation:

Acute excessive dosage with OPANA can cause skeletal muscle flaccidity, frigid wet skin, limited pupils, difficulty breathing, and in rare instances, cardiac arrest, low blood pressure, edema of the lungs, either partial or total airway obstruction, abnormal snoring, and even death.

Treatment of Overdose:

  • Priorities in the event of an overdose include the establishment of assisted or controlled ventilation, if necessary, and the restoration of a patent and protected airway.
  • Naloxone or nalmefene, which are opioid antagonists, are particular remedies for respiratory depression brought on by an opioid overdose.


Opana, also known as oxymorphone, is a powerful opioid that acts on brain receptors to treat extreme pain. Given the risks of addiction, caution is essential. When all other options are exhausted and careful administration and monitoring are required, Opana Oxymorphone 40mg is the medication of choice for chronic pain.

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